Research team identifies differences between benign and pathogenic gene variants

An international team of researchers led by Cleveland Clinic’s Lerner Research Institute has performed for the first time a wide-scale characterization of missense variants from 1,330 disease-associated genes. Published in Proceedings of the National Academy of Sciences, the study identifies features associated with pathogenic and benign variants that reveal the effects of the mutations at […]

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Low quantity and quality of muscle predicts poor outcomes in colon cancer surgery

Low muscle quality and quantity are both predictive of poor outcomes in colon resection surgery, according to a new study published in JAMA Surgery. Carla Prado, a researcher in the University of Alberta’s Faculty of Agricultural, Life & Environmental Sciences, and her team followed 1,630 patients who received a diagnosis of Stage I to Stage […]

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‘Fast’ MRI detects breast cancers that 3-D mammograms may miss

Beth Reisboard, 76, was relieved in 2018 when she received the results from her annual mammogram: “Negative.” But her OB-GYN suggested she have a second screening. Reisboard has dense breasts, which means there are certain cancers that mammography may not be sensitive enough to detect. Surprised, Reisboard scheduled an appointment to undergo an abbreviated MRI […]

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Utilizing telecare to motivate depressed individuals who take opioids into treatment

Drawing upon their experience and expertise in telehealth, collaborative care models, substance use disorders, depression and health information technology, Indiana University School of Medicine and Regenstrief Institute faculty have been awarded $3.9 million over four years to collaborate with Kaiser Permanente Washington Health Research Institute scientists on a trial to optimize treatment for opioid use […]

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